Isothermal Titration Calorimeter (iTC-200)

Isothermal Titration Calorimeter (iTC-200)

The Microcal iTC-200 is designed to make very precise calculations of the binding energetics of analyte molecules, most commonly a protein and ligand. Through precise measurements of enthalpy changes produced by titration of one analyte into the other, this instrument can calculate binding constants and stoichiometry with a high degree of accuracy. This machine uses a far smaller sample volume than previous models (only 200 L), opening this instrument to experiments with analytes that are difficult to produce in quantity.